Guidance route search device, navigation device, and method of searching guidance route

ABSTRACT

This invention provides a container set for mixing at the time of administration allowing a secure mixing operation in administration without dripping chemicals by maintaining the sealed state of the mouth of liquid container particularly until the containers are connected to each other for mixing while storing two contents in the containers, respectively, wherein a tuber plug  5  is detachably fitted to the mouth part  4  of a vial  1  and a cap  30  is fitted to the mouth part  22  of the liquid container  2 . The cap  30  has a first structure  31  fitted liquid-tightly to the mouth part  22  and a second structure  32  fitted liquid-tightly to the first structure  31  and having a connection port part  32   a  connectable liquid-tightly to the mouth part  4 . The second structure  32  is movable from a first position where the internal space of the liquid container  2  is sealed from the outside air to a second position on the axial inner side of the first position, and when the second structure is positioned at the second position, the vial  1  connected to the connection port part  32   a  is allowed to communicate with the internal space of the liquid container  2.

FIELD OF THE INVENTION

The present invention relates to a set of containers for mixing itscontents at the time of administration, which is capable of storingfreeze-dried solid form of medication and either solvent or dispersionmedium separately, and for mixing them at once in administration.

Background Art

As this kind of conventional container set for mixing at the time ofadministration, an applicant of the present invention has conventionallydeveloped such that are disclosed in Japanese published unexaminedapplication 2001-9471 gazette and Japanese published unexaminedapplication H08-280807 gazette. These conventional mixing containers inadministration are composed of a solid ingredient storing part and aliquid ingredient storing part separately from each other. At the timingof use, these storing parts are connected so that the solid ingredientis dissolved or dispersed into the liquid ingredient, and this medicalagent is sprayed.

Said conventional type of container set for mixing at the time ofadministration is filled up with the solid ingredient and the liquidingredient and tight sealed under sterile conditions in a packingfactory, kept and transported with being kept sterile, and at the timingof use, the inside of which is not exposed to the ambient air. So it iscapable of being handled highly hygienically and preventing beneficialeffect from being lost by conducting dissolution just before use.

However, there is a problem that overall height of the container in thetiming of use 50 is high so that the performance for storage andhandling would be less effective, because the container has each storingunits to store two medicines (i.e. the solid ingredient and the liquidingredient) separately before mixing, and even after mixing, thecontainer still equips with the storing units integrally. Moreover,according to the intention of use or the behavior of the medicine, thereis a case that there is no problem if the solid ingredient and theliquid ingredient are exposed to the quantity of ambient air at thetiming of mixing operation in administration. In said case, there is noneed to use said conventional mixing container in administration, whichwould be a cause of a new construction of manufacturing facilities andefficiency reduction during filling up at the packing factory. In thiscase, conventionally, a vial bottle, a solvent container different fromthe vial bottle, and a spray bottle are sold as a set, and at the timingof use, a solid ingredient in the vial bottle is mixed and dissolvedinto a liquid ingredient in the solvent container and this mixedmedicine is filled in the spray bottle for use. However, when thesethree containers are packed and sold as a set, packing materials willbecome bigger, the cost for storing and transporting will be moreexpensive and it will not be preferable for the environment because thevial bottle and the solvent container will be unwanted so that thequantity of wastes will increase.

Additionally, during transferring of the medicine between the solventcontainer and the vial bottle, the medicine may seep even with a carefultreatment so that it will be difficult to mix two medicines in a conciserate and also, if the wet medicine attaches outside of the container,bacteria would breed so that it would be a problem in a view of anaspect of good hygiene.

SUMMARY OF THE INVENTION

The object of the present invention is to provide a container set formixing at the time of administration, which is able to store each of twocomponents in each container and carry out a mixing operation inadministration surely with-out seeping liquid medicine by the meanswherein especially airtight state of the mouth of the liquid containeris kept until the containers are connected each other.

The container set for mixing at the time of administration in thisinvention may comprise a first container which has a first openingportion, a plug body which is removably attached to the first openingportion so that an internal space of the first container is sealed offagainst ambient air, a second container which has a second openingportion, a cap which is attached to the opening of the second container.As just described, by forming the first container and the secondcontainer separately and sealing each of the openings with the plug bodyor the cap, it is able to put aseptically the freeze-dried medicine andthe liquid ingredient, which is its solvent and so on, into thecontainers with the conventional facilities and processes. The firstcontainer may preferably be comprised of the vial bottle, and the secondcontainer be preferably comprised of a blow-formed resin bottle with avapor barrier property suited to store the liquid ingredient. Eachcontainer may have a body portion, which has a bottom, on its openingportion integrally, and internal space of this body portion may be usedas a storing room for content. The plug which seals the opening of thefirst container is preferable a rubber plug made from Butyl-rubber andthe like. To make the plug sealing more assured, an aluminum foil on theplug body may be put or the cap may be attached on the opening portionof the first container in a manner wherein the plug body is covered andheld.

Said cap may have a first cap part which is attached to the secondopening portion liquid tightly and a second cap part which is fittedliquid tightly to the first cap part and has a connecting openingportion which is connectable to the first opening portion liquidtightly. This second cap part may be relatively movable from a firstposition where the first and second cap parts seal internal space of thesecond container off from ambient air, to a second position which islocated axially inward from the first position. Also, when the secondcap part is located at the second position, a connecting path may beformed in the cap, the path connecting internal space of the firstcontainer and internal space of the second container, the internal spaceof the first container connected to a connecting opening portion of thesecond cap part. Additionally, said connecting opening portion may beconfigured to be connectable to the opening of the first container, whenthe second cap part is located at the first position. Also, each of thecap parts may be formed in a tube shape and internal space of these cappats may serve as said connecting path.

According to the container set for mixing at the time of administrationof the present invention, during transport and storage, solid ingredientsuch as freeze dried medicine may be stored in the first container inthe antiseptic condition, and liquid ingredient which serves as solventor dispersion medium of the solid ingredient may be stored in the secondcontainer in the antiseptic condition. When a patient or a nursingattendant mixes in administration, first of all, the plug body isdetached from the opening of the first container and the connectingopening portion of the second cap part of the second container turnedupside down is connected to the first opening portion which opensupwardly. In this time, the second cap part is still located at thefirst position and the second opening portion keeps being sealed so thatthe liquid ingredient in the second container does not leak. Next, thesecond container connected to the opening portion of the first containeris pushed to the first container side, the second cap part is pushed bythe first container and moved from the first position to the secondposition, said connecting path is formed in the cap, and the liquidingredient in the second container is displaced in to the firstcontainer without leaking. After mixing (dissolution or deconcentration)efficiently, the second container is turned with being connected to thefirst container, so that the mixed liquid medicine is displaced from thefirst container turned upside down to the second container passingthrough the connecting path. Then, the first container and the cap aredetached from the opening portion of the second container, and adischarging unit such as an eye-dropper nozzle or a pump spray unit isattached to the second opening portion, so that it is capable to use thesecond container as a discharging container of the mixed liquidmedicine.

In the said container set for mixing at the time of administration ofthe present invention, the first cap part may be configured to engage tothe second opening undetachably when the second cap part is located atthe first position, and such that said engagement to the second openingportion is released when the second cap part is located at the secondposition. With this configuration, until the second cap part is movedfrom the first position to the second position by said mixing operationin administration, the first cap part is not able to be detached fromthe second opening portion, so that it is able to prevent the cap frombeing detached from the second container without discretion andassuredness of mixing operation is ensured.

Also, the first cap part may have an engaging portion which isreleasably engaged to the second opening portion in a manner whereinmoving in an axial direction to the second opening portion is prevented.The second cap part may have a lock portion and a release portion, thelock portion holding forcibly the engaging portion so as to engage tothe second opening portion when it is located at the first position, therelease portion engaging the engaging portion so as to be moved to adirection such that said engagement is released when it is located atthe second position. By that, until the second cap part is moved fromthe first position to the second position by said mixing operation inadministration, the first cap part is not able to be detached from thesecond opening portion, so that it is able to prevent the cap from beingdetached from the second container without discretion and assuredness ofmixing operation is ensured. Moreover, when the second cap part is movedto the second position, the releasing portion is engaged to the engagingportion, so that an engagement between the engaging portion and thesecond opening portion released without fault, so the cap is easilyreleased without fault from the second container after the mixingoperation.

Also, the first cap part may have an inside tube portion which isextended outwardly in the axial direction of the second opening portionand a plug which is fixed at an end of the inside tube portion. Theexternal diameter of the plug may be smaller than the internal diameterof the first opening portion, an opening portion may be formed betweenthe plug and the inside tube portion, the connecting opening portion maybe fitted into the first opening portion, the inside tube portion is fitinto the connecting opening portion, the plug may be fitted liquid-tightinto an end portion of the connecting opening portion when the secondcap part is located at the first position so that the connecting path isclosed, and the plug may be released from the connecting opening portionwhen the second cap part is located at the second position so that theconnecting path is formed.

Moreover, said plug may be formed separately from the inside tubeportion and the said plug is attached to the inside tube portion fromthe axially end side, so that an external rim of the plug is engaged toan end surface of the connecting opening portion of the second cap part.By that, the second cap part is prevented from detaching from the firstcap part by the plug, and structures are simplified and fabrications areprogressed.

Also, the plug and the inside tube portion may be formed integrally, theplug and the inside tube portion may be connected integrally throughmultiple connecting ribs which are spaced and placed peripherally, andthe space between the connecting ribs may serve as an opening portion.By that, it is able to aim reducing of numbers of structure units, sothat it is able to aim further cost reduction.

Moreover, the container set for mixing at the time of administration inthe present invention may have a stopper mounted detachably. The stopperis contact to the second cap so as to be prevented from moving from thefirst position to the second position. By that, it is able to preventthe second cap part from being accidentally moved to the secondposition, the opening portion of the second container from being opened,and the liquid ingredients from being exposed to the ambient air.Additionally, the stopper may be detachably attached to an externalperipheral of the body portion of the second container, or to anexternal peripheral of the first cap part.

Also, the connecting opening portion of the second cap part is to befitted in to the first opening. The second cap part may further have anengaging piece which is located radially outside of the connectingopening portion and extends to an axial end side. The first opening mayhave a flange portion projected radially outside, and said engagingpiece may be engaged axially to a rim of a base end side of the flangeportion when the connecting opening portion is fitted in to the firstopening portion. By that, when the connecting opening portion isconnected to the opening portion of the first container, the firstopening portion is held by the engaging piece formed around the externalperipheral of the connecting opening portion, so that the cap may bedetached together with the first container from the second container bydetaching the first container from the second container after mixingoperation finishes. Therefore, it is able to simplify an operation of apro-process after mixing and shorten the amount of time from mixing tousing.

Also, the container set for mixing at the time of administration in thepresent invention, the first cap part may mainly comprise a first tubeportion which is mounted onto the external peripheral side of the secondopening portion and a second tube portion which is linked to the firsttube portion. An internal diameter of the second tube portion may besmaller than the internal diameter of the second opening portion. Thesecond cap part may have a plug which is fitted into a base end portionof the second tube portion. The plug may be formed to close theconnecting path when the second cap part is located at the firstposition and form the connecting path when the second cap part islocated at the second position. Moreover, the first cap part may furtherhave a third tube portion which is linked to an other end side of thesecond tube portion. The connecting opening portion of the second cappart may be fitted into the first opening portion. The second cap partmay have a flange portion which extends radially outwardly from the baseend portion of the connecting opening portion. Said flange portion maybe fitted into the third tube portion and an internal peripheral surfaceof the third tube portion may have an engaging protrusion portion whichengaged to the flange portion in a manner wherein the second cap part isprevented from moving from the first position to the second position.The third tube portion may be elastically deformable in an axiallyexternal direction in a manner wherein the engagement between theengaging protrusion portion and the flange portion is released.

By using aforementioned container set for mixing at the time ofadministration, it is possible to operate following procedure for mixingin administration. The procedures of the present invention for mixing inadministration are: (1) the solid ingredient is sealed and stored in thefirst container and the liquid ingredient which is to be solvent orcarrier fluid is sealed and stored in the second container; (2) at thetiming of use, the first container is opened while a sealing storingstate of the second container is kept, the second container is connectedto the opening portion of the first container, the connecting path whichconnects the internal space of the first container and the internalspace of the second container is formed, the first ingredient and thesecond ingredient are mixed through the path, and the mixed liquidmedicine is stored in the second container; (3) after said mixing, thefirst container is detached from the second container, the dischargingunit which is used for discharging liquid in the second container isattached to the second container so that the mixed liquid medicine inthe second container becomes dischargeable, and the second containerused as a liquid ingredient container is used as a mixed medicinedischarging container. By that, at the timing of storing or shippingbefore mixing in administration, the number of containers whichcomprises a set are two, so that the package will not be too bigcompared to the case wherein there is a spray container formedseparately, so it is possible to attempt to handle easily and reduce thecost. Additionally, the second container, which is used as storingcontainer for the liquid ingredient before the mixing in administration,is reused as the discharging container for the mixed liquid medicine, sothat the cost reduction by reducing constituent elements, wastereduction and the improvement of the environment may be attempted.

In the aforementioned present process invention, it is more preferablethat the first container comprises the bottle body made from a materialwhich has a good gas barrieracy such as glasses (e.g. a conventionalvial bottle). By that, by freeze-drying in the bottle body, the solidingredient is stored in the bottle body in the antiseptic condition, andespecially, it is possible to store unstable freeze-dried medicine inthe glass container stably.

Additionally, to hold the plug body attached on the first opening of thefirst container without fault, it is possible to attach a top member(e.g. A ring shaped top with a lock mechanism disclosed in Japanesepublished unexamined application H09-278051 gazette) on the firstopening. This top member may have an engaging member which has multipletalons around a rim of a discotic top plate portion, and a cylindricalholder member which is fixed to an external side of the multipleengaging talons of said engaging member. The engaging talon, of which alower end side is elastically deformable radially expanded and reduced,may extended from the rim of the top plate portion to down below. Anupper end of the engaging member and a lower side of the holder memberare molded integrally, trough the breakable connecting portion. Whenthis top member is used, connecting portion is broken by pushing theholder member downward relatively to the engaging portion, the holderportion is attached onto the external peripheral of the multipleengaging talons, and the multiple engaging talons are deformed radiallyinwardly by the holder member, so that this engaging talon is engaged tothe external peripheral of the first opening portion. Preferably,engaging portions (concave portion or protrude portion), which areengaged each other when the holder member is attached to the externalperipheral of the engaging talons, may be formed on each internalperipheral surface and external peripheral surface, so that the holdermember is prevented from detaching accidentally. Also, thread portions,which are screwing each other, may be formed on the internal peripheralsurface of the holder member and the external peripheral surface of theengaging talons, so that the holder member is screwed to the multipleengaging talons. By that, it is capable to prevent the holder memberfrom being detached accidentally and to detach the holder member withcomparatively light strength by rotating the holder member, while theengaging talons are strongly pushed toward radially inward. Also, whenthe holder member which is attached to the external peripheral of theengaging member is pulled up, the engaging portion which engages to theexternal rim of a neighborhood of the upper end of the engaging membermay be located on a internal peripheral of the neighborhood of the lowerend of the holder member, so that it is capable to detach the engagingmember from the opening portion as the holder is pulled up. This topmember is preferably used for holding the plug body made fromButyl-rubber which is attached to the opening portion of the glass vialbottle and improving the assuredness of the air tightness, and may bereused in other than the container set for mixing at the time ofadministration in the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 Longitudinal sectional view of a container set for mixing at thetime of administration of a first embodiment of the present invention,especially, (a) shows a resin bottle which is used as both a solventcontainer and a spray bottle and (b) shows a vial bottle;

FIG. 2 Front view of the resin bottle of the mixing container inadministration

FIG. 3 Process drawing of the mixing process in administration of themixing container in administration;

FIG. 4 Longitudinal sectional view of the container set for mixing atthe time of administration of a second embodiment of the presentinvention, especially, (a) shows a discharging nozzle as a dischargingunit, (b) shows a vial bottle and (c) shows a resin bottle for use as asolvent container and an otological medicine container;

FIG. 5 Process drawing of the mixing process in administration of themixing container in administration;

FIG. 6 Longitudinal sectional view of a container set for mixing at thetime of administration of a third embodiment of the present invention,especially, (a) shows a discharging nozzle as a discharging unit, (b)shows a vial bottle and (c) shows a resin bottle for use as a solventcontainer and an eye drops discharging container;

FIG. 7 Process drawing of the mixing process in administration of themixing container in administration;

FIG. 8 Longitudinal sectional view of a container set for mixing at thetime of administration of a forth embodiment of the present invention,especially, (a) shows a resin bottle for use as a solvent container anda spray bottle, (b) shows a vial bottle;

FIG. 9 Front view of the resin bottle of the mixing container inadministration

FIG. 10 Process drawing of the mixing process in administration of themixing container in administration.

THE PREFERRED EMBODIMENTS

With reference to the attached drawings, the present invention willhereinafter be described by way of an embodiment thereof.

FIGS. 1 to 3 illustrate a mixing container in administration of a firstembodiment of the present invention. This mixing container inadministration has mainly a vial bottle 1 (a first container) forstoring a solid ingredient made from freeze-dried medicine, a resinousbottle 2 (a second container) for storing a liquid ingredient as solventor fluid for the solid ingredient. Additionally, said liquid itself mayhave an active ingredient. This set can be preferably used as, forexample, a pump spraying container for collunarium, and also, used in adlibitum application.

The vial bottle 1 is made from glass and it has an opening portion 4 (afirst opening portion) integrated with an upper end of a body 3 whichhas a cylindrical shape with a bottom. A plug body 5 made from rubbersuch as Butyl-rubber is liquid tightly plugged in this opening portion 4and a top member 6 (a plug body block) is coated on it to prevent theplug body 5 from accidentally being pulled off. Also, an upper end ofthe opening portion 4 has a flange portion 7 which is projectingradially. Said top member 6 is attached to the opening portion 4 byengaging to this flange portion 7. The flange portion 7 may be formed onaxial midstream of the opening portion 4. Forming the flange portion 7on axial midstream causes a structure of an upper surface of an openingof the vial I to be two-tier and there is a gap between the flangeportion 7 and a brim portion 9 of the plug 5, so that it enables pullingoff the plug body 5 easily by putting a tip of fingers into this gap.

The plug body 5 has an airtight stopper 8 which is fitted in the openingportion 4 and the brim portion 9 which touches an upper surface of theopening portion 4 integrally. An external diameter of the brim portion 9is almost the same as the flange portion 7 of the opening portion 4. Ata side portion of the airtight stopper 8, a concave part 10 whichextends from its lower end upwardly is formed. An half plugged state, inwhich an upper end of the concave part 10 is located above an upper endof the opening portion 4, the concave part 10 forms an air pass betweenthe plug body 5 and the opening portion 4. On the other hand, a pluggedstate, in which the plug body 5 is pushed till the brim portion 9touches the upper surface of the opening portion 4, the upper end of theconcave part 10 is located inward (below) the upper end of the openingportion 4 so that the opening portion 4 is sealed air tightly.

The top member 6 has an engaging member 13 which has multiple talons 12around a rim of a discotic top plate portion 11, and a cylindricalholder member 14 which is fixed to an external peripheral side of themultiple engaging talons 12 of said engaging member 13. These engagingmembers 13 and the holder member 14 may be, at the timing of theproduction, molded integrally through a connecting portion which is ableto be broken easily. At the timing of capping which follows filling upthe vial bottle 1 with freeze-dried medicine, the connecting portion maybe broken by pushing the holder member 14 and both of them may beseparated. Additionally, it is preferable to make the top member 6 fromresin which is discarded by incinerating.

In the illustrated embodiment, eight engaging talons 12 are placed atthe same intervals surrounding around the opening portion 4 and there isa slit between two engaging talons next to each other. Each engagingtalon 12, of which a lower end side is elastically deformable radiallyexpanded and reduced, is formed as a long plate, extended from the rimof the top plate portion 11 to down below, and formed wherein the lowerend side is expanded radially outwardly more than the upper end side ina non-transformed state. On an inside peripheral surface of the engagingtalon, there is an engaging protrusion portion 15 which is engageable tothe flange portion 7 of the opening portion 4. There is a stretchingportion 16 which projects radially outwardly at the lower end of theengaging talon 12.

The holder member 14 comprises a tube whose internal diameter is almostthe same as an external diameter of the top plate portion 11, and aflange portion 17 which projects radially outwardly at the upper end ofsaid holder member 14. A length of an axis of the holder member 14 isalmost as long as a length of an axis of said engaging member 13.

To store freeze-dried medicine (solid ingredient) air tightly underaseptic condition into said vial bottle 1, first of all, drug solutionis filled in the sterilized vial bottle 1 in a clean room. Secondly, theplug body 5 is half plugged into the opening portion 4 of the vialbottle 1 and the liquid ingredient is vaporized in the freeze-dryingdevice so that the vaporized steam is discharged through the air pass ofthe concave part 10 to the outside of the bottle. Next, the plug body 5is plugged completely into the opening portion 4 so that thefreeze-dried medicine is air tightly sealed and kept in the room of thevial bottle 1. Then, the engaging member 13 of the top member 6 is liedover the plug body 5 and the opening portion 4 and the holder member 14is pushed strongly, so that the connecting portion 15 gets broken, theholder member 14 is attached around the external peripheral side of theengaging part 13, the engaging talons 12 are elastically deformedradially internally by the holder member 14, and the engaging protrusionpart 15 is engaged to the flange portion 7 of the opening portion 4. Inthis top-member-6-fixed-state, the plug body 5 is held completely by thetop member 6 unless the holder member 14 is separated from the engagingmember 13.

The bottle 2 is such that a cylindrical opening portion 22 is integrallymolded to an upper end of a bottomed cylindrical shaped body 21. Abottomed cylindrical pedestal 23 is fixed to a lower part of the bottle2. The bottle 2 is formed in the manner wherein the body portion 21 is,at the middle in the axial direction of it, radially bulged and formed,and its diameter is getting gradually smaller as it goes from the middlein the axial direction to a bottom. The opening portion 22 of an upperend of the bottle 2 has a cylindrical shape which opens upwardly. Itsexternal peripheral surface has a screw portion 22 a, which is used forscrewing an after mentioned pump spraying device, and a flange portion22 b, which is located at a lower side (base side) of the screw portionand projected axially outwardly, is formed integrally.

In the opening portion 22 of the bottle 2, a cap 30, which is mainlycomprised of a cylindrical first cap part 31 and a cylindrical secondcap part 32, are attached. During shipping or storing of the bottle 2filled with the liquid ingredient, the opening portion 22 is sealed airand water tightly, while, at the timing of use, the cap 30 is used as aconnecting adapter to the vial bottle 1, so that a two ingredientsmixing process is easily carried out.

The first cap part 31 has a ring-shaped base portion 31 a which touchesan upper surface of the bottle opening portion 22 and a cylindricalsealing tube portion 31 b which is extended from said base portion 31 a,water tightly fitted to the bottle opening portion 22 and by that it isattached to the opening portion 22 water tightly. Also, the first cappart 31 has multiple engaging pieces 31 c (engaging portion) extendedaxially inwardly (downwardly) from a brim of an outer peripheral of thebase 31 a. These multiple engaging pieces 31 c are placed equally spacedin a peripheral direction and formed freely deformable in a mannerwherein a lower end of the each engaging piece 31 c is expanded radiallyoutwardly. An engaging protrusion part 40 which engages to a lowersurface of the flange 22 b of the bottle opening portion 22, so that theengaging pieces 31 c are de-engageably engageable to the bottle openingportion 22 in a manner that moving in a axial direction of the bottleopening portion 22 is prevented. Moreover, each engaging piece 31 c hasa turn-backed guiding engaging portion 31 d.

Also the first cap part 31 has a cylindrical inside tube portion 31 ewhich is extended axially outwardly (upwardly) from a brim of an innerperipheral of the base 31 a, a rod 31 f which integrally formed at anend portion of said inside tube portion 31 e, and a plug 31 g which isfixed at an end of the inside tube portion 31 e by being fitted to therod 31 f. In the present embodiment, in the components of the first cappart, only the plug 31 g is formed separately and the other componentsare formed integrally by an injection molding and the like. An externaldiameter of the plug 31 g is smaller than an internal diameter of themouth portion 4 of the vial bottle 1. Also, there is an opening portion41 formed between the plug 31 g plus the rod 31 f and the inside tubeportion 31 e, so that the liquid ingredient in the bottle 2 freely flowsinto an external peripheral side of the plug 31 g.

On the other hand, the second cap part 32 is fitted liquid tightly ontothe first cap part 31 and has a connecting opening portion 32 a which isliquid tightly connectable to the opening portion 4 of the vial bottle1. The second cap part 32 is movable relatively to the first cap partfrom the first position (see also FIG. 1), wherein internal space of thebottle 2 is sealed from the ambient air by the first and the second cappart 31 and 32, to the second position which is located axially inwardlymore than the first position. When the second cap part 32 is located atthe second position, a connecting pass which connects internal space ofthe bottle 2 and internal space of the vial bottle 1 connected to theconnecting opening portion 32 a of the second cap part 32 is formed.

In more detail, the second cap part 32 has a flange portion 32 b whichextends from an end portion of the connecting opening portion 32 a,multiple, in a peripheral direction, of engaging pieces 32 c which islocated radially outside of the connecting opening portion 32 a andextends from the flange portion 32 b to an axial end side (outside), areleasing portion 32 d which extends from the flange portion 32 b to anaxial base side (inside), and a main body portion 32 e which extendsfrom an external rim of the flange 32 b to the axial base side. Saidengaging pieces 32 c has an engaging protrusion part 42 on its insidesurface close to an end. When the connecting opening portion 32 a isfitted in and connected to the opening portion 4, the second cap part 32is capable of zipping up the opening portion 4 of the vial bottle 1 bythe manner wherein the engaging protrusion part 42 is axially engaged toa base side rim of the flange portion 7 of the vial bottle 1.

Also, a locking portion 32 f, which forcibly holds down the engagingpieces 32 c from an external surface side in a manner wherein theengaging pieces 31 c of the first cap part 31 are engaged to the flangeportion 22 b of the bottle opening 22 when the second cap part islocated at the first position, inflation-formed on internal peripheralsurface of the main body portion 32 e of the second cap part 32, so thatthe first cap part is engaged to the bottle opening 22 without beingseparated. Said releasing portion 32 d is axially separated from theguiding engaging portion 31 d of the first cap part 31 and an endportion of said releasing portion 32 and the guiding engaging portion 31d is located axially opposite. When the second cap part 32 is moved tothe second position, the end portion of the releasing portion 32 d isengaged to the guiding engaging portion 31 d, so that it moves theengaging pieces 31 c to the direction wherein an engagement between theengaging pieces 32 c of the first cap part 31 and the flange portion 22b of the bottle opening portion 22 is released (i.e. radially outward)so that the engagement between the first cap part 31 and the bottleopening portion 22 is released. To conduct this engagement releasesmoothly, both engaging surfaces of the end portion of the releasingportion 32 d and the guiding engaging portion 31 d are formed tapered.

Also, a neighboring structure of the plug 31 g is explained in moredetail as followed. An end portion of the connecting opening portion 32a is radially gathered up in a needle-nosed manner. When the second cappart 32 is located at the first position, an external peripheral rim ofthe plug 31 g is engaged to an end surface of the connecting openingportion 32 a, and an end opening of the connecting opening portion 32 ais sealed water and air tightly by the plug 31, so that the connectingpass is closed. By fitting the connecting opening portion 32 a in theopening portion 4 of the vial bottle 1 and moving it to the secondposition, the plug 31 g is separated axially from the connecting openingportion 32 a and inserted into the opening portion 4 of the vial bottle1 so that said connecting pass is formed.

Also, in this embodiment, a stopper 44, which is touched to a lower endsurface of the main body portion 32 e, is detachably attached to thebottle body 21 so that the second cap part 32 is prevented from movingfrom the first position to the second position.

Additionally, in the example illustrated in Figs., an outside cap 45 isscrewed further on said cap 30 and this outside cap 45 preventsespecially periphery of the plug 31 g from being contaminated. It ispossible to pack the cap 30 with a silver foil instead of the outsidecap 45.

Next, the mixing procedure of said container set for mixing at the timeof administration is explained with reference to FIG. 3.

The procedure (a) shows features at delivery, in other words, a state atthe timing of the transportation and storage. When it is used, detachthe top plate portion 6 and the plug body 5 from the opening portion 4of the vial bottle 1 and the outside cap 45 of the bottle 2 is detachedas illustrated in a procedure (b). Then, as illustrated in a procedure(c) and (d), the bottle 2 is turned upside down and the connectingopening portion 32 a is pushed into the opening portion 4 of the vialbottle 1 so that both containers 1 and 2 are connected. The second cappart 32 is prevented from moving to the second position by the stopper44, so that it does not happen that an end of the connecting openingportion 32 a opens before finishing connecting and causes leaking.

Next, the stopper 44 is removed and the bottle 2 is further pushed, asshown in the procedures (e) and (f), so that the second cap part 32 ismoved axially relatively to the first cap part 31, the plug 31 g isreleased from the connecting opening portion 32 a, the connecting passwhich connects internal space of the vial bottle 1 and one of the bottle2, so that the liquid ingredient in the bottle 2 flows into the vialbottle 1 through the connecting pass. Also, in this time, the releasingportion 32 d of the second cap part 32 is engaged to the guidingengaging portion 31 d of the engaging pieces 31 c of the first cap part31, the engaging pieces 31 c are expanded their diameter radiallyoutwardly by the releasing portion 32 d, and the engagement between theengaging pieces 31 c and the bottle opening portion 22 is released.

After mixing the liquid ingredient and the solid ingredientsufficiently, as shown in the process (g), it is turned upside downaltogether so that the bottle 2 is located to lower side and the vialbottle 1 is located to upper side, and all of the mixed medicine flowsinto the bottle 2. Then, as shown in the process (h), the vial bottle 1is pulled away from the bottle 2, so that the cap 30 is pulled awaytogether with the vial bottle 1 since the engagement between the cap 30and the bottle opening portion 22 has already been released as mentionedabove. As shown in the process (i), a separately prepared dischargingunit 50 such as pump spray unit is attached to the bottle openingportion 22 so that the bottle 2, which has been used as a container forthe liquid ingredient before mixing, is used as a discharging container.

Additionally, the pump spray device 50 has a cylindrical cap memberwhich is screwed to the opening portion 22, a suction tube which sucksup the liquid stored in internal space of the bottle 2 from a bottom ofthe room, a pump portion which generate a suction force to suck up theliquid through the suction tube, and a spraying portion which is usedfor spraying the sucked liquid to the outside. The suction tube, thepump portion and the spraying portion are formed axially in asuccession, and the pump portion is fixed and held by the cap member.The suction tube is located at the middle of the axis of the bottle andextends axially along almost all length of the bottle.

Additionally, said each constructional elements are made from thematerial ad libitum, however, preferably, the rubber plug, the vialbottle, the plug, the top portion of the vial bottle, and bottle aremade from Butyl-rubber, glass, low-density polyethylene, polypropylene,and high-density polyethylene, relatively. Other constructional elementsare preferably made from polypropylene or high-density polyethylene.

FIG. 4 and 5 show a container set for mixing at the time ofadministration in a second embodiment of the present invention. It isespecially preferably used as an otological dissolving container inadministration. Hereinafter, the similar structures as said firstembodiment are numbered the same symbol and of which the explanationsare omitted, different structures and effects will be described andexplained.

As the rubber plug 5 of the vial bottle 1, such that conventionally wellknown are used, and after the rubber plug 5 is fitted into the openingportion 4, the whole vial bottle 1 is packed with aluminum.

The first cap part 31 does not have said engaging pieces and is screwedonto the external peripheral of the bottle opening 22. Also the plug 31g is molded integrally with other constituent elements and the plug 31 gand the inside tube portion 31 e is connected integrally throughmultiple connecting ribs 31 h which is peripherally spaced and placed.The space between the connecting ribs 31 h is an opening portion 41.This plug 31 g is only fitted into the inner peripheral of theconnecting opening portion 32 a and it is not engaged to the end surfaceof the connecting opening portion 32 a to prevent the second cap part 32from releasing. In this embodiment, the main body portion 32 e of thesecond cap part 32 is fitted onto the first cap part and there is anunder cut portion 46 at this fitting point so that the second cap part32 is prevented from coming off from the second cap part 31.

Also, the releasing portion 32 d, the guiding engaging portion 31 d andthe lock portion 32 f in the first embodiment are not in the secondembodiment. Moving the second cap part 32 to the second position doesnot automatically release engaging (screwing) between the first cap partand the bottle opening portion 22. Therefore, in the pro-processes aftermixing two liquids, the vial bottle 1 and the bottle 2 are relativelyrevolved, so that the cap 30 is detached from the bottle opening portion22. At this time, to prevent the second cap part 32 from spinning freelyto the first cap part 31, an engaging point, wherein the second cap partstaying at the second position and the first cap part 31 are engaged inthe direction of rotating operation, is located at the proper position,for example, the lower end portion of the main body portion 32 e of thesecond cap part 32. Additionally, the discharging container 50 in thisembodiment has a discharging nozzle.

The mixing process in administration in this embodiment is almost thesame as the one in the first embodiment, so there is a reference to FIG.5 and detail descriptions are omitted.

FIG. 6 and 7 show a container set for mixing at the time ofadministration in a third embodiment of the container set for mixing atthe time of administration. Only the shape of a bottle is different fromthe one in the second embodiment, so the same numbers are used and theexplanations are omitted. In addition, it is especially preferably usedas an eye dropper.

FIG. 8 to 10 show a container set for mixing at the time ofadministration in a forth embodiment of the present invention and it isespecially preferably used as an otological dissolving container inadministration. The vial bottle 1, its plug configurations, and thebottle 2 are the same as said first embodiment, so the same numbers areused and the explanations are omitted but the different configurationsand the different effects are explained.

The cap 50 which is mainly comprised of a cylindrical first cap part 51and cylindrical second cap part 52 is attached to the opening portion 22of the bottle 2 of this embodiment. During shipping or storing of thebottle 2 filled with the liquid ingredient, the opening portion 22 issealed air and water tightly with the cap 50, while, at the timing ofuse, the cap 50 is used as a connecting adapter to the vial bottle 1, sothat a two ingredients mixing process is easily carried out withoutfail.

The first cap part 51 is mainly comprised of a cylindrical first tubeportion 51 a which is screwed onto the external surface side of thebottle opening portion 22, a cylindrical second tube portion 51 b whichis formed in a succession from the first tube portion 51 a, acylindrical third tube portion 51 c which is formed in a succession froman axial end side of the second tube portion 51 b, and a cup-shapedholder 51 d which is formed in a succession from an axial end side ofthe third tube portion 51 c. The first tube portion 51 a has a threadportion, which screwed onto a screw portion 22 a of the externalperipheral of the bottle opening portion, on its internal peripheralsurface. An external diameter and an internal diameter of the secondtube portion 51 b are smaller than the internal diameter of the bottleopening portion 22, in the illustrated example, a base end portion ofthe second tube portion 51 b is inserted into the bottle opening portion22. The first tube portion 51 a and the second tube portion 51 b areintegrally connected through a flange portion 51 e, and a lower surfaceof this flange portion 51 e is facing to the opening upper surface ofthe bottle opening portion 22. To acquire air tightness and liquidtightness between the first cap part 51 and the bottle opening portion22, there is a rubber packing 53 between the flange portion 51 e and thebottle opening portion 22.

A third tube portion 51 c is comprised in a manner wherein it is capableof fitting onto the opening portion 4 of the vial bottle 1, and when thethird tube portion 51 c is fitted onto the opening portion 4, anengaging protrusion part 54, which is axially engaged to a base endportion of the flange portion 7 of the opening 4, is formed on aninternal peripheral surface of the third tube portion 51 c. Also, asshown in FIG. 8 and FIG. 9, the third tube portion 51 c has a slit 55 sothat a certain point in a circumferential direction of the third tubeportion 51 c is capable of being elastically deformed radiallyoutwardly, to have the third tube portion 51 c fitted easily onto theopening portion 4. The holder portion 51 d has a shape which fits in theshape of a shoulder and body portion of the vial bottle 1. When thethird tube portion 51 c is fitted onto the opening portion 4, anexternal peripheral surface of the upper side of the vial bottle 1 isheld by the internal peripheral surface of the holder portion 51 d.

The second cap part 52 is mainly comprised of a cylindrical connectingopening portion 52 a which is air tightly and liquid tightly fitted intothe opening portion 4 of the vial bottle 1, a cylindrical joint portion52 b which is connected in succession to said connecting opening portion52 a and fitted into the second tube portion 51 b axially slidable, acylinder-with-a-bottom-shaped plug 52 c which is fitted into an axialbase end portion of the second tube portion 51 b, and a flange portion52 d which is formed from an axial base end portion of the connectionopening portion 52 a to a radially outward direction. In these mainstructures, only the plug 52 c is separately formed and the otherstructures are integrally formed. Also, an end portion of the plug 52 cand a base end portion of the joint portion 52 b are attached.Additionally, it is possible to form the plug 52 c integrally to thejoint portion 52 b. Also, it is possible to combine accordingly theflange portion 52 d and the connecting opening portion 52 a as aseparate portion part. The second cap part 52 is relatively movable tothe first cap part 51 from a first position wherein the internal spaceof the bottle 2 is sealed from the ambient air by the first and thesecond cap part 51 and 52 (see also FIG. 8) to a second position whichis located inward in the axial direction of the bottle 2 from the firstposition (see also FIG. 10(d)). When the second cap part 52 is locatedon the second position, a connecting path which connects the inside roomof the bottle 2 and the inside room of the vial bottle 1 which connectedto the connecting opening portion 52 a of the second cap part 52 isformed in the cap.

In other words, the plug 52 c has an opening portion 56 which goesthrough an inside to an outside on its peripheral wall, and when thesecond cap part 52 is moved to the second position, the opening portion56 of the plug 52 c is exposed under a base end portion of the secondtube portion 51 b so that said connecting path is opened. On the otherhand, when the second cap part 52 is on the first position, the openingportion 56 of the plug 52 c is stored above the lower end portion of thesecond tube portion 51 b and said connecting path is blocked by thisplug 52 c.

Also, the flange portion 52 d of the second cap part 52 is fitted intothe third tube portion 51 of the first cap part 51. When the second cappart 52 is located at the first position, the flange portion 52 d isprevented from moving to the second position of the second cap part 52by engaging to the engaging protrusion part 54 axially. The certainpoint in a circumferential direction of the third tube portion 51 c iscapable of being elastically deformed radially outside, as stated above.So the third tube portion 51 c is forcibly pushed and expanded outradially when the vial bottle 1 connected to the connecting openingportion 52 a is pushed strongly, and the engagement between the flange52 d and the engaging protrusion part 54 is released so that therelative movement to the second position becomes capable.

Additionally, a cover cap 45 is attached to a top end portion of theholder portion 51 d, so that the interior of the first and the secondcap part are prevented from contamination.

Next, with reference to FIG. 10, mixing process of the aforementionedcontainer set for mixing at the time of administration is explained. Theprocess (a) shows delivery form i.e. the state at the timing of shippingor storing. When it is used, first of all, the top member 6 and the plug5 is removed from the opening portion 4 of the vial bottle 1 and thecover cap 45 of the bottle 2 is removed as shown in the process (b).Next, the bottle 2 is turned upside down, as shown in the process (c),and the connecting opening portion 52 a is pushed into the openingportion 4 of the vial bottle 1 so that both containers 1 and 2 areconnected. Then, the bottle 2 is further pushed, as shown in the process(d) and (e), the second cap part 52 is moved axially relatively to thefirst cap part 51, the opening portion 56 of the plug 52 c is exposed tothe internal space of the bottle, the connecting path which connects theinternal space of the vial bottle 1 and the internal space of the bottle2 is formed in the cap 50, and the liquid ingredient in the bottle 2flows into the vial bottle 1 through the connecting path.

After mixing the solid ingredient and the liquid ingredientsufficiently, as shown in the process (f), whole structure is turnedupside down, so that the bottle 2 is located in lower side and the vialbottle 1 is located in upper side, and all of the mixed liquid medicineflows into the bottle 2. Then, as shown in the process (g), by holdingthe holder portion 51 d and rotating whole structure of the first cappart 51, the cap 50 and the vial bottle is removed all together from thebottle opening portion 22. Additionally, the process from (d) to (g) arecarried out with holding the holder portion 51 d, so that it is possibleto accomplish simplification and speeding up of the series ofoperations.

Then, as shown in the process (h), by attaching a separately prepareddischarging unit 50 such as a spray pump bottle to the opening portion22, it is possible to use the bottle 2, which has been used as a liquidingredient container before mixing, as a discharging container.

In the present invention, in administration, when the first containerand the second container are connected so that the solid ingredient andthe liquid ingredient are mixed, it is capable to precisely generatemixed liquid medicine in a defined mixing rate without leaking theliquid ingredient and handle it hygienically. Also, after carrying outthe mixing operation, the mixed liquid is stored in the secondcontainer, and the discharging unit is attached to this container, andit can be used as a discharging container such as a spray container, sothat it is able to operate mixing in administration precisely, at thesame time, with an attempt to make a package smaller and reduce wasteproducts.

1. A container set for mixing at the time of administration comprising:a first container having a first opening portion; a plug attachedremovably to the first opening portion so that an internal space of thefirst container is sealed off against ambient air; a second containerhaving a second opening portion; a cap attached to the second openingportion of the second container; wherein the cap comprises a first cappart and a second cap part, the first cap part attached to the secondopening portion liquid tightly, the second cap part fit liquid tightlyto the first cap part and having a connecting opening portion which isconnectable to the first opening portion liquid tightly; the second cappart is relatively movable from a first position where the first andsecond cap parts seal internal space of the second container off fromambient air to a second position which is located axially inward fromthe first position; and the cap configured such that a connecting pathis formed therein when the second cap part is located at the secondposition, the path connecting internal space of the first containerconnected to a connecting opening portion of the second cap part andinternal space of the second container.
 2. A container set for mixing atthe time of administration as set forth in claim 1, wherein the firstcap part is configured to engage to the second opening undetachably whenthe second cap part is located at the first position, and such that saidengagement to the second opening portion is released when the second cappart is located at the second position.
 3. A container set for mixing atthe time of administration as set forth in claim 1, wherein the firstcap part comprises an engaging portion which is releasably engaged tothe second opening portion in a manner wherein moving in an axialdirection to the second opening portion is prevented, the second cappart comprises a lock portion and a release portion, the lock portionholding forcibly the engaging portion so as to engage to the secondopening portion when it is located at the first position, and therelease portion engaging the engaging portion so as to be moved to adirection such that said engagement is released when it is located atthe second position.
 4. A container set for mixing at the time ofadministration as set forth in claim 1, wherein the first cap partcomprises an inside tube portion extended outwardly in the axialdirection of the second opening portion and a plug fixed at an end ofthe inside tube portion, an external diameter of the plug is smallerthan the internal diameter of the first opening portion, an openingportion is formed between the plug and the inside tube portion, theconnecting opening portion is fitted into the first opening portion, theinside tube portion is fit into the connecting opening portion, the plugis fitted liquid-tightly into an end portion of the connecting openingportion when the second cap part is located at the first position sothat the connecting path is closed, and the plug is released from theconnecting opening portion when the second cap part is located at thesecond position so that the connecting path is formed.
 5. A containerset for mixing at the time of administration as set forth in claim 4,wherein said plug is formed separately from the inside tube portion andattached to the inside tube portion from the axially end side, so thatan external rim of the plug is engaged to an end surface of theconnecting opening portion of the second cap part.
 6. A container setfor mixing at the time of administration as set forth in claim 4,wherein the plug and the inside tube portion is formed integrally, theplug and the inside tube portion is connected integrally throughmultiple connecting ribs which are spaced and placed peripherally, andthe space between the connecting ribs serve as an opening portion.
 7. Acontainer set for mixing at the time of administration as set forth inclaim 1, further comprising a stopper mounted detachably which iscontact to the second cap part so as to be prevented from moving fromthe first position to the second position.
 8. A container set for mixingat the time of administration as set forth in claim 1, wherein theconnecting opening portion of the second cap part is configured to befitted in to the first opening, the second cap part further comprises anengaging piece which is located radially outside of the connectingopening portion and extends to the axial end side, the first opening hasa flange portion projected radially outside, and said engaging piece isengaged axially to a rim of a base end side of the flange portion whenthe connecting opening portion is fitted in to the first openingportion.
 9. A container set for mixing at the time of administration asset forth in claim 1, wherein the first cap part comprises a first tubeportion which is mounted onto the external peripheral side of the secondopening portion and a second tube portion which is linked to the firsttube portion, an internal diameter of the second tube portion is smallerthan the internal diameter of the second opening portion, the second cappart comprises a plug which is fitted into a base end portion of thesecond tube portion, and the plug is configured to close the connectingpath when the second cap part is located at the first position and formthe connecting path when the second cap part is located at the secondposition.
 10. A container set for mixing at the time of administrationas set forth in claim 9, wherein the first cap part further comprises athird tube portion which is linked to an other end side of the secondtube portion, the connecting opening portion of the second cap part isconfigured to fit into the first opening portion, the second cap partfurther comprises a flange portion which extends radially outwardly fromthe base end portion of the connecting opening portion, the flangeportion is fitted into the third tube portion, an internal peripheralsurface of the third tube portion has an engaging protrusion portionwhich engaged to the flange portion in a manner wherein the second cappart is prevented from moving from the first position to the secondposition, the third tube portion is elastically deformable in an axiallyexternal direction in a manner wherein the engagement between theengaging protrusion portion and the flange portion is released.